Natural Polysaccharides as Film Former: a Feasibility Study for Development of Rapid Dissolving Films of Ondansetron Hydrochloride
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چکیده
Ondansetron is a highly selective serotonin (5-HT3) receptor blocker which inhibits serotonin to bind with serotonin 5-HT3 receptors and hence prevent the vomiting reflex induced by serotonin. This work aimed to develop rapid dissolving films of ondansetron for the treatment of chemotherapy induced nausea and vomiting. Rapid dissolving films were prepared by solvent casting method using pullulan PI 20 as film former and PG and tween 80 as plasticizer. Bitterness of Ondansetron was masked by forming inclusion complex with HPβ-CD. The complex was evaluated by XRD, DSC and FT-IR. Optimized films were evaluated for mechanical properties, surface pH and dissolution characteristics. The combination of pullulan PI 20 and PG:tween 80 and xanthan gum exhibited excellent mechanical properties (Tensile strength 6.1 N/mm2), drug content (96.6 %) and disintegrating time (14 sec). The research work done here suggested the exciting possibility of ondansetron as rapid dissolving Film.
منابع مشابه
Fast Dissolving Sublingual Films of Ondansetron Hydrochloride: Effect of Additives on in vitro Drug Release and Mucosal Permeation
Ondansetron hydrochloride, a 5 HT3 antagonist is a powerful antiemetic drug which has oral bioavailability of 60% due to hepatic first pass metabolism and has a short half-life of 5 h. To overcome the above draw back, the present study was carried out to formulate and evaluate fast dissolving films of ondansetron hydrochloride for sublingual administration. The films were prepared from polymers...
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